The surprisingly good 2013 film Drinking Buddies was about multiple characters that worked at a local brewery. In one of the scenes, Kendrick’s character actually got drunk when the group was playing a drinking game that she continued to lose at.
Bob Hoskins And John Leguizamo
Admitted in Leguizamo’s autobiography, the box office bomb Super Mario Bros. was a trainwreck of a film to make. Both of the lead actors drank more and more throughout filming, and Hoskins repeatedly admitted in an interview that participating in this movie was the biggest mistake of his career.